Application

Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat# ALD00602). The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Legal Information

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesisPSI on OpenFlask